Glucokinase in B-cell-depleted islets of Langerhans.
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چکیده
منابع مشابه
Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.
It was reported previously that isolated human islets from individuals with type 2 diabetes mellitus (T2DM) show reduced glucose-stimulated insulin release. To assess the possibility that impaired bioenergetics may contribute to this defect, glucose-stimulated respiration (Vo(2)), glucose usage and oxidation, intracellular Ca(2+), and insulin secretion (IS) were measured in pancreatic islets is...
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Incretins such as glucagon-like peptide 1 (GLP-1) are released from the gut and potentiate insulin release in a glucose-dependent manner. Although this action is generally believed to hinge on cAMP and protein kinase A signaling, up-regulated beta cell intermediary metabolism may also play a role in incretin-stimulated insulin secretion. By employing recombinant probes to image ATP dynamically ...
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Isolation of rat islets of Langerhans was carried out by using collagenase and the destruction of exocrine tissue was performed through the injection of Hanks' solution into the common bile duct. The identification of the islets was done by techniques including the use of a stereomicroscope against a black background. Vital staining was done by an injection of neutral red solution through t...
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Introduction: Islet transplantation has become a promising treatment for type I diabetes mellitus due to recent success since the development of the Edmonton Protocol. Islet culture prior to transplantation is standard practice in several clinical islet programs. High-density islet culture is desirable because it reduces space and handling requirements during culture, but it exacerbates oxygen ...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 1987
ISSN: 0022-1554,1551-5044
DOI: 10.1177/35.10.3305701